Dried parsley shot from above on white background

Parsley & It’s Use in Kidney Related Disorders

Parsley (Petroselinum crispum)

Parsley would have to be one of the world’s most popular culinary herbs. Grown for its tasty green leaves, parsley provides a source of vitamin C, iron and vitamin A. It is a member of the carrot family and native to the Mediterranean. The word parsley comes from the Greek, meaning ‘rock celery’. Parsley became popular throughout Europe in the Middle Ages, where it was commonly grown in monasteries and royal gardens. Parsley has a rich folklore and history behind it, there was a time when there was superstition surrounding the herb, it was believed parsley could only be grown by pregnant women and witches.

Apparently, banqueting Greeks wore parsley crowns to stimulate their appetite and promote good humour. Traditionally parsley is known as a warming food and blood tonic with an affinity for the bladder, kidney and stomach meridians. Parsley contains a volatile oil, apiol, which has carminative, circulatory stimulant, aromatic digestive and urinary antiseptic properties.

As kidney disease is one of the world’s leading public health issues, it is important to asses the significant role plants may play in this area of health.

Part Used- Whole herb, root and seed

Contraindications- The seed and heavy consumption of the seed should be avoided in pregnancy. Renal failure.

Preparation- Obviously we use parsley as a culinary herb, it is also taken as an infusion and the root and seeds are taken as a decoction. Herbal preparations are also found in tablet/capsule form and as a liquid herbal extract.

Parsley, Petroselinum crispum – Wisconsin Horticulture

parsley and kidney disease and kidney stones

Actions & Applications

Parsley is used by herbalists for its diuretic, emmenagogue, expectorant, carminative, antispasmodic and hypotensive actions. Due to some of the parsley’s constituents, it has been long credited as a strong diuretic and the seed especially has been used for oedematous conditions and urinary stones. As mentioned, it is also a close relative to celery and like celery seed, it has been found to increase the elimination of acidic metabolites giving it an application in conditions such as gout and arthritic conditions.

I’m sure most of you have used the fresh herb in cooking!  Parsley provides a rich source of vitamins A, C and K. In traditional medicine, parsley has three main areas of usage; an effective diuretic, as an emmenagogue to stimulate the menstrual process and thirdly as a carminative to ease colic pain and wind. I will be focusing on its actions on the kidney and its application in kidney stones and supporting healthy blood pressure to help prevent further kidney damage.

IJMS | Free Full-Text | Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms (mdpi.com)

Parsley and Kidney Stones

Kidney stones and the formation of stones is one of the oldest known diseases of the urinary tract, unfortunately with a relapse rate of 50% every 5-10 years. It is the third most common health issue found in urinary disease. The prevalence of stones has been found to be higher in males (10%) during a lifetime, compared to females (3%), although newer studies are now showing a shift of prevalence to stones in females almost equal to males. The aetiology behind the condition is multifactorial, complex and not entirely understood.

Urinary Stones | Department of Urology (unc.edu).

IJMS | Free Full-Text | Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms (mdpi.com)

Symptoms

Symptoms of renal stones will vary from no symptoms at all to:

  • blood in the urine
  • urinary obstruction
  • vague flank pain
  • severe colicky pain which is not relieved by pain medication
  • nausea, vomiting
  • fever and chills

These symptoms may lead to urinary urgency, frequency and/or upset stomach.

Types of Stones

  • Calcium stones
  • Uric acid stones
  • Struvite stones
  • Cystine stones

About 85% of stones are composed of calcium, the remainder is composed of various substances such as uric acid, cystine or struvite.

Potential Causes

Stones may form when the urine becomes saturated with salts that have the ability to cause a stone or it can be due to the urine lacking the normal inhibitors of stone formation. Stones are also often seen in people with certain disorders such as hyperparathyroidism, dehydration and renal tubular acidosis. People who have had bariatric surgery may also be at an increased risk of stone formation.

Genetics, diet, excess body weight, certain supplements and medications are also among the many causes of kidney stones.

Kidney stones – Symptoms and causes – Mayo Clinic

Stones in the Urinary Tract – Kidney and Urinary Tract Disorders – MSD Manual Consumer Version (msdmanuals.com)

Urinary Stones | Department of Urology (unc.edu)

A 2018 study published in the International Journal of Molecular Sciences reported that the various pharmacological actions parsley possessed; were found to have antioxidant, anti-inflammatory, diuretic, nephron-protective and anti-hypertensive activity. The study showed the beneficial actions may be due to its constituents which include flavonoids, carotenoids, coumarins, ascorbic acid and tocopherol. Research showed parsley prevented the nucleation and precipitation of calcium oxalate and urine supersaturation in a rat model of calcium stone formation. The authors concluded the high content of chlorophyll and magnesium within parsley was a potential reason for its inhibitory effect towards dehydration of calcium oxalate and excessive oxalate production. Parsley was found to be effective in regulating urinary pH where calcium oxalate crystals could be maintained as dispersed particles and their elimination facilitated. The study concluded parsley may be used as a promising anti-urolithiasis remedy.

IJMS | Free Full-Text | Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms (mdpi.com)

Hypertension

High blood pressure (hypertension) is a common condition that impacts the arteries. When you have high blood pressure, the force of the blood pushing against the artery walls is high making it harder for the heart to pump blood, putting a lot of pressure on the heart, the circulatory system and the kidneys. Kidneys also play an important role in maintaining healthy blood pressure as uncontrolled high blood pressure is capable of causing chronic kidney disease. When blood pressure elevates extra pressure is put on blood vessels throughout the body, including the kidneys. If the kidneys get to the point they cannot function at a healthy capacity, extra fluid builds up and waste is not removed creating a cycle of hypertension and kidney damage.

The American College of Cardiology and the American Heart Association divides hypertension into 4 categories:

  • Normal blood pressure. Blood pressure is 120/80 mm Hg or lower.
  • Elevated blood pressure. The top number ranges from 120 to 129 mm Hg and the bottom number is below, not above, 80 mm Hg.
  • Stage 1 hypertension. The top number ranges from 130 to 139 mm Hg and the bottom number is between 80 and 89 mm Hg.
  • Stage 2 hypertension. The top number is 140 mm Hg or higher or the bottom number is 90 mm Hg or higher.

hypertension and kidney disease

Hypertension can cause a variety of other health concerns such as:

  • Heart attack
  • Stroke
  • Aneurysm
  • Heart failure
  • Narrowed or torn blood vessels in the eyes
  • Metabolic syndrome
  • Memory loss

Symptoms of Hypertension

Most people with high blood pressure will not experience any symptoms and you can have high blood pressure for years without even recognising it.

The following symptoms aren’t specific, they usually don’t occur until hypertension is severe or life-threatening.

You may experience:

  • Headaches
  • Shortness of breath
  • Nosebleeds

High blood pressure (hypertension) – Symptoms and causes – Mayo Clinic

Healthy blood pressure is monitored differently in those with chronic kidney disease compared to those without a kidney issue. If you are under a doctor for kidney disease, they will monitor your blood pressure closely and they will guide you on the healthy range.

Parsley-Its Use in Hypertension

Nitric Oxide

Parsley has been found to be high in nitrates, nitrates help dilate the blood vessels which will improve the blood flow and support healthy blood pressure. Evidence indicates, nitrates consumed via the diet lowers blood pressure in healthy humans. Nitric oxide (NO) plays an important part in maintaining vascular homeostasis, reduced NO production or bioavailability has been associated with cardiovascular and metabolic diseases. Evidence accumulated in a 2013 study concluded a dose of nitrate as low as 3 mmol reduced systolic blood pressure by 3 mmHg. Authors suggested the potential mechanism by which dietary nitrate supports healthy blood pressure and improves endothelial function is due to the ability to increase vasodilation; inhibiting mitochondrial reactive oxygen species production and platelet aggregation.

The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies | Nutrition Research Reviews | Cambridge Core

Nitrate in leafy vegetables, culinary herbs, and cucumber grown under cover in Estonia: content and intake: Food Additives & Contaminants: Part B: Vol 3, No 2 (tandfonline.com)

Carotenoids

Carotenoids are a class of fat-soluble pigments mainly found in plants, they have been found to possess potent anti-inflammatory properties and may help support healthy blood pressure via the reduction of pro-inflammatory cytokines and markers of inflammation. Parsley contains three carotenoids, lutein, zeaxanthin, and beta-carotene. A 2015 study looking at carotenoids and their potentially positive role in supporting cardiovascular health found that anti-inflammatory activity may help fight against cardiovascular risk factors such as hyperlipidaemia, hypertension, insulin resistance and obesity.

Carotenoids: potential allies of cardiovascular health? – PubMed (nih.gov)

8 Impressive Health Benefits and Uses of Parsley (healthline.com)

As well as being a tasty culinary herb, you can see parsley can play a potential role in supporting healthy blood pressure and may be a suitable choice in the management of urinary stones. Please remember as with any dietary/ supplemental change in those with a chronic health concern, to make sure you consult your health professional first.

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References

  • Wood, R. (2010). The New Whole Foods Encyclopaedia, Penguin Books
  • Mills, S. (1991). The Essential Book of Herbal Medicine, Penguin Books Ltd
  • Capicchiano, D, Chin, F (2020). The Kidney Disease Solution, 3, Empowered Health Solutions Pty. Ltd.

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